What Is A Melanocyte
Melanocytes are skin cells found in the upper layer of skin. They produce a pigment known as melanin, which gives skin its color. There are two types of melanin: eumelanin and pheomelanin. When skin is exposed to ultraviolet radiation from the sun or tanning beds, it causes skin damage that triggers the melanocytes to produce more melanin, but only the eumelanin pigment attempts to protect the skin by causing the skin to darken or tan. Melanoma occurs when DNA damage from burning or tanning due to UV radiation triggers changes in the melanocytes, resulting in uncontrolled cellular growth.
Naturally darker-skinned people have more eumelanin and naturally fair-skinned people have more pheomelanin. While eumelanin has the ability to protect the skin from sun damage, pheomelanin does not. Thats why people with darker skin are at lower risk for developing melanoma than fair-skinned people who, due to lack of eumelanin, are more susceptible to sun damage, burning and skin cancer.
What Is Most Dangerous Skin Cancer
1. Nodular melanoma
An most dangerous form of melanoma that looks various from common melanomas they are raised from the start and have an even coloring . This kind of melanoma grows really rapidly and needs to be dealt with as quickly as possible.
2. Basal cell carcinoma
This is the most typical but least dangerous kind of skin cancer. It grows slowly, generally on the head, neck and upper torso. It may look like a lump or dry, scaly area. It can be red, pale or pearly in color. As it grows, it may ulcerate or resemble a sore that does not recover correctly.
3. Squamous cell carcinoma
This type of skin cancer is not as dangerous as melanoma but may infect other parts of the body if not treated. It grows over some months and appears on skin most often exposed to the sun. It can be a thickened, red, flaky spot that may bleed quickly, crust or ulcerate.
How Does Skin Cancer Become A Life
You may wonder how cancer on the surface of your skin becomes a life-threatening cancer. It seems logical to think you could just scrape off the skin with the cancer cells or even remove the cancerous skin lesion with a minor skin surgery and thats all that would be needed. These techniques are successfully used if cancer is caught early.
But if skin cancer isnt caught early, something thats just on my skin can grow and spread beyond the immediate area. Cancer cells break away and travel through the bloodstream or lymph system. The cancer cells settle in other areas of your body and begin to grow and develop into new tumors. This travel and spread is called metastasis.
The type of cancer cell where cancer first started called primary cancer determines the type of cancer. For example, if malignant melanoma metastasized to the lungs, the cancer would still be called malignant melanoma. This is how that superficial skin cancer can turn into life-threatening cancer.
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Can Skin Cancer Be Prevented
Skin cancer is almost entirely preventable. Making a part of your life, avoiding sunburn, and checking your skin regularly will help prevent further damage to your skin.
Protect your skin from UV radiation and help prevent skin cancer by:
- slipping on sun-protective clothing: cover your shoulders, neck, arms, legs and body.
- slopping on sunscreen thats rated SPF 30+ or higher, broad-spectrum and water resistant.
- slapping on a hat that shades your face, neck and ears.
- seeking shade under trees, umbrellas and buildings from direct sunlight and reflective surfaces.
- sliding on sunglasses that wrap around your face to protect your eyes and surrounding skin.
- staying away from sun lamps, solariums or sunbeds, which emit dangerous levels of UV radiation.
UV radiation from the sun varies depending on time of day, season, where you live and cloud coverage. Protect your skin whenever UV Index levels are above 3. Use Cancer Council Australias free SunSmart app to check the UV Index for your area any time.
Most Australians will get enough vitamin D even with sun protection at UV level 3 or above. Babies and children should be protected from the sun, since they are particularly vulnerable to UV radiation harm.
While using fake tanning cream isnt harmful to your skin, it offers no protection from UV radiation. You still need to protect yourself from the sun.
Most Dangerous Form Of Skin Cancer
Florida isnt nicknamed The Sunshine State for no reason! Our sunny weather attracts tourists to our beaches, resorts, and theme parks year-round.
Unfortunately, all that sun can be harmful! One in five Americans will develop skin cancer over the course of a lifetime. The biggest risk factor is regular, intense exposure to UV rays. Some people are genetically predisposed to develop skin cancer, which increases their risk further.
But, you may ask, what is the most dangerous form of skin cancer?
Melanoma is the most dangerous form of skin cancer. The American Cancer Society estimates that 73,000 cases of melanoma will be diagnosed this year alone.
Melanomas cancerous growths are caused by DNA damage to skin cells. The damage causes mutations that quickly spread and form malignant tumors in the basal layer of the epidermis, usually starting in melanocytes pigment-producing cells.
If not caught at an early stage, melanoma spreads at a rapid rate. This disease can be fatal if left untreated, as it can spread to other organs and cause further complications.
Fortunately, if caught early on, melanoma is generally curable.
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Which Type Of Skin Cancer Is The Most Dangerous
Melanoma vs Non-melanoma skin cancer
There are two main categories of skin cancer: melanoma and non-melanoma. Between these types, melanoma is the most dangerous form of skin cancer, although non-melanoma skin cancers are the most common.
Non-melanoma skin cancers refer mostly to basal cell carcinoma and squamous cell carcinoma two types of skin cancer that are, in most cases, treatable without becoming life-threatening.
Melanoma skin cancer begins in melanocyte cells in the deepest layer of skin, also known as the hypodermis or subcutaneous tissue, while non-melanoma cancers are found in the upper and middle layers of skin, called the epidermis and dermis, respectively.
Symptoms On Black And Brown Skin
On dark skin, it may be easier to feel a lesion than see it. People with black skin may be more likely to find a lesion on a part of the body that has little exposure to the sun, according to the American Academy of Dermatology.
Skin cancer can affect people with any skin color, but those with brown or black skin are more likely to receive a diagnosis at a later stage. This may be due to a lack of awareness of how skin cancer appears on skin colors other than white.
Anyone who notices an unusual change in their skin should seek medical advice as soon as possible.
The medical community has developed two ways to spot the early symptoms of melanoma. This is the most dangerous type of skin cancer.
A person can use the ABCDE method or the ugly duckling method.
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How Dangerous Is Melanoma
Melanoma is usually curable when detected and treated early. Once melanoma has spread deeper into the skin or other parts of the body, it becomes more difficult to treat and can be deadly.
- The estimated five-year survival rate for U.S. patients whose melanoma is detected early is about 99 percent.
- An estimated 7,180 people will die of melanoma in the U.S. in 2021.
There Are Many Skin Cancer Treatment Options
According to DeClerck, how your skin cancer is treated depends on several factors, including:
- The type of cancer
- The size of the cancer
- The growth pattern of the cancer
- The location of the cancer
Once youre diagnosed, your doctor will go over the options for treatment, she says. The options may include topical creams, scrape and burn procedures, surgical excision or Mohs micrographic surgery, which is a specialized surgery that evaluates each layer of the skin to make sure the cancer is completely gone.
Surgical procedures are usually done in the doctors office or clinic with topical numbing medicine. Radiation may also be used for some basal cell or squamous cell cancers.
For some high-risk skin cancers, such as melanoma and some squamous cell carcinomas, a lymph node biopsy may also be recommended to make sure the cancer hasnt spread, DeClerck says.
In addition to surgery, melanoma treatment might also involve chemotherapy, radiation, immunotherapy or targeted therapy drugs, if necessary.
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Benign Tumors That Develop From Other Types Of Skin Cells
- Seborrheic keratoses: tan, brown, or black raised spots with a waxy texture
- Hemangiomas: benign blood vessel growths, often called strawberry spots
- Lipomas: soft growths made up of fat cells
- Warts: rough-surfaced growths caused by some types of human papilloma virus
Most of these tumors rarely, if ever, turn into cancers. There are many other kinds of benign skin tumors, but most are not very common.
For More Information About Skin Cancer
National Cancer Institute, Cancer Information Service Toll-free: 4-CANCER 422-6237TTY : 332-8615
Skin Cancer Foundation
Media file 1: Skin cancer. Malignant melanoma.
Media file 2: Skin cancer. Basal cell carcinoma.
Media file 3: Skin cancer. Superficial spreading melanoma, left breast. Photo courtesy of Susan M. Swetter, MD, Director of Pigmented Lesion and Cutaneous Melanoma Clinic, Assistant Professor, Department of Dermatology, Stanford University Medical Center, Veterans Affairs Palo Alto Health Care System.
Media file 4: Skin cancer. Melanoma on the sole of the foot. Diagnostic punch biopsy site located at the top. Photo courtesy of Susan M. Swetter, MD, Director of Pigmented Lesion and Cutaneous Melanoma Clinic, Assistant Professor, Department of Dermatology, Stanford University Medical Center, Veterans Affairs Palo Alto Health Care System.
Media file 5: Skin cancer. Melanoma, right lower cheek. Photo courtesy of Susan M. Swetter, MD, Director of Pigmented Lesion and Cutaneous Melanoma Clinic, Assistant Professor, Department of Dermatology, Stanford University Medical Center, Veterans Affairs Palo Alto Health Care System.
Media file 6: Skin cancer. Large sun-induced squamous cell carcinoma on the forehead and temple. Image courtesy of Dr. Glenn Goldman.
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Where Does Skin Cancer Develop
Skin cancer is most commonly seen in sun-exposed areas of your skin your face , ears, neck, arms, chest, upper back, hands and legs. However, it can also develop in less sun-exposed and more hidden areas of skin, including between your toes, under your fingernails, on the palms of your hands, soles of your feet and in your genital area.
Which Skin Cancer Is The Fastest Growing And Most Dangerous
4.4/5most dangerousskin cancer
Similarly, it is asked, what type of skin cancer spreads the fastest?
Advertisement. Merkel cell carcinoma tends to grow fast and to spread quickly to other parts of your body. Treatment options for Merkel cell carcinoma often depend on whether the cancer has spread beyond the skin.
Beside above, which type of skin cancer is the least deadly? Basal Cell CarcinomaThis is the least dangerous type of skin cancer because it tends to grow slowly and rarely spreads beyond its original site.
Also asked, how fast can skin cancer spread?
Melanoma can grow very quickly. It can become life-threatening in as little as six weeks and, if untreated, it can spread to other parts of the body. Melanoma can appear on skin not normally exposed to the sun.
What happens if you ignore skin cancer?
Its very rare for a basal cell cancer to spread to other parts of the body. But if its left untreated, basal cell cancer can grow into nearby areas and invade the bone or other tissues beneath the skin. If not removed completely, basal cell carcinoma can come back in the same place on the skin.
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Look Out For An Ugly Duckling
The Ugly Duckling is another warning sign of melanoma. This recognition strategy is based on the concept that most normal moles on your body resemble one another, while melanomas stand out like ugly ducklings in comparison. This highlights the importance of not just checking for irregularities, but also comparing any suspicious spot to surrounding moles to determine whether it looks different from its neighbors. These ugly duckling lesions or outlier lesions can be larger, smaller, lighter or darker, compared to surrounding moles. Also, isolated lesions without any surrounding moles for comparison are considered ugly ducklings.
When To Seek Medical Care For Skin Cancer
Many people, especially those who have fair coloring or have had extensive sun exposure, periodically check their entire body for suspicious moles and lesions.
Have your primary health care provider or a dermatologist check any moles or spots that concern you.
See your health care provider to check your skin if you notice any changes in the size, shape, color, or texture of pigmented areas .
If you have skin cancer, your skin specialist or cancer specialist will talk to you about symptoms of metastatic disease that might require care in a hospital.
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The Ugly Duckling Method
The ugly duckling method works on the premise that a personâs moles tend to resemble one another. If one mole stands out in any way, it may indicate skin cancer.
Of course, not all moles and growths are cancerous. However, if a person notices any of the above characteristics, they should speak with a doctor.
I’ve Been Diagnosed With Melanomawhat Happens Next
Doctors use the TNM system developed by the American Joint Committee on Cancer to begin the staging process. Its a classification based on three key factors:
T stands for the extent of the original tumor, its thickness or how deep it has grown and whether it has ulcerated.
What Is Breslow depth?
Breslow depth is a measurement from the surface of the skin to the deepest component of the melanoma.
Tumor thickness: Known as Breslow thickness or Breslow depth, this is a significant factor in predicting how far a melanoma has advanced. In general, a thinner Breslow depth indicates a smaller chance that the tumor has spread and a better outlook for treatment success. The thicker the melanoma measures, the greater its chance of spreading.
Tumor ulceration: Ulceration is a breakdown of the skin on top of the melanoma. Melanomas with ulceration are more serious because they have a greater risk of spreading, so they are staged higher than tumors without ulceration.
N indicates whether or not the cancer has already spread to nearby lymph nodes. The N category also includes in-transit tumors that have spread beyond the primary tumor toward the local lymph nodes but have not yet reached the lymph nodes.
M represents spread or metastasis to distant lymph nodes or skin sites and organs such as the lungs or brain.
After TNM categories are identified, the overall stage number is assigned. A lower stage number means less progression of the disease.
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How Does Ultraviolet Radiation Cause Skin Cancer
Were exposed to UV rays every time we step outside into the beautiful Florida sun. Normal exposure isnt necessarily dangerous. People who use sun tanning beds frequently, who work outside regularly, who dont use proper UV protection, or lay out on the beach a lot are at a higher risk for developing melanoma.
Prolonged exposure to UV rays causes damage to your skin cells DNA. While our bodies can repair normal amounts of damage done by UV rays, accumulated damage can cause cells to start growing at an irregular rate. This, in turn can lead to skin cancer.
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As we head into summer, its time to kick your safe skin practices into high gear. All individuals should apply a broad spectrum SPF every day, and watch their local UV forecast for daily updates when outside activities are planned.
Why? Skin cancer is the most common form of cancer in the United States. One in five Americans will be diagnosed with the disease in his or her lifetime. There are more new cases of skin cancer every year than breast, prostate, lung and colon cancers combined, according to the U.S. Centers for Disease Control and Prevention.
Although family history and your natural skin pigmentation play a role in your risk, the number-one thing that causes skin cancer is exposure to UV rays.
Erin Gilbert, M.D., Ph.D., a spokesperson for the Skin Cancer Foundation, offered these guidelines to weather.com in 2014: Avoid the sun when its at its peak wear sun-protective clothes, such as a hat always wear a broad-spectrum SPF. Reapply sunscreen every two hours, or after swimming or sweating.
Its a myth that most sun damage occurs in childhood, so theres nothing you can do about it as an adult, Dr. Gilbert said.
Twenty-three percent of sun damage happens before youre 18, but it is cumulative. Its never too late to start protecting yourself, she said. Your melanoma risk doubles if youve had more than five severe sunburns at any age. Dont let a sunburn or a tan deter you from seeing your dermatologist or wearing sun screen the next day.
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Dr Russell Akin Midland Dermatology
Dr. Russell Akin, MD, RPh. FACMS, FAAD, is a board-certified dermatologist and fellowship-trained Mohs surgeon at Midland Dermatology. Dr. Akin specializes in skin cancer treatments, Mohs surgery, and other dermatological procedures with patients ages 12 and up at Midland Dermatology.
For more information or to schedule an appointment at Midland Dermatology, call 432-689-2512.
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When Should I See My Doctor
Its important to check your own skin regularly to find any new or changing spots.
See your doctor or dermatologist straight away if you notice any changes to your skin, such as:
- an ‘ugly duckling’ a spot that looks or feels different to any others
- a spot that changes size, shape, colour or texture over time
- a sore that doesnt go away after a few weeks
- a sore that itches or bleeds
See the ‘ABCDE’ of skin cancer, above.