Monday, April 15, 2024
HomeCarcinomaWhat Is Well Differentiated Squamous Cell Carcinoma

What Is Well Differentiated Squamous Cell Carcinoma

Stages Of Squamous Cell Carcinoma

Squamous Cell Carcinoma
  • print page
  • Bookmark for later

Cancer staging is a way of describing how extensive a cancer is. The stage is related to tumor size. It also relates to whether the cancer has spread from the original tumor to other parts of the body. The cancer stage helps you and your doctor to develop a treatment plan. It also provides information about survival. Squamous cell carcinoma stages use a system called TNM.1,2 This cancer staging system is used by most hospitals and medical systems.3 Once your doctor has categorized the T, N, and M, these values are combined to assign a cancer stage.2

What Does It Mean If The Following Terms Are Used To Describe The Adenocarcinoma: Papillary Micropapillary Acinar Mucinous Or Solid

These terms describe different types of lung adenocarcinoma, which are based on how the cells look and are arranged under the microscope . Some tumors look basically the same throughout the tumor, and some can look different in different areas of the tumor. Some growth patterns have a better prognosis than others. Since some tumors can have a mixture of patterns, the pathologist canât always tell all the types contained in a tumor just based on a biopsy that samples only a small part of the tumor. To know what types a tumor contains, the entire tumor must be removed.

What Does It Mean If There Is Vascular Lymphatic Or Lymphovascular Invasion

These terms mean that cancer is present in the blood vessels and/or lymph vessels of the esophagus. If the cancer has grown into these vessels, there is an increased chance that it could have spread out of the esophagus. However, this doesnt mean that your cancer has spread. Discuss this finding with your doctor.

Read Also: What Is The Survival Rate Of Invasive Ductal Carcinoma

Features Of T Categories

The T categories describe the main tumor based on its thickness, the presence of high-risk features, and invasion.2 Your doctor begins to gather this information by doing a skin biopsy. If the tumor is invasive, you will need imaging tests.

  • Size. The longest dimension of the tumor is measured in centimeters.
  • Invasion. The tumor is categorized by how far it has invaded the body. Invasion of the facial bones is categorized as T3. Invasion of bones in the rest of the body or the base of the skull is T4. Your doctor determines this using magnetic resonance imaging or computed tomography scan.
  • High-risk features. High-risk features refer to the risk that the cancer returns or spreads . High-risk features of SCC are:2
  • > 2 mm thick or Clark level IV
  • Growing around a nerve
  • Located on the ear or lip
  • Poorly differentiated or undifferentiated cells. Differentiation means how much the cancer cells look like the normal tissue that it came from. Poorly differentiated cells grow and spread more quickly.

You May Like: What Foods Prevent Skin Cancer

What Does It Mean If My Report Says Typical Carcinoid Or Atypical Carcinoid Tumor

Moderately differentiated squamous cell carcinoma. HE ...

Carcinoid tumors are a special type of tumor. They start from cells of the diffuse neuroendocrine system. This system is made up of cells that are like nerve cells in certain ways and like hormone-making endocrine cells in other ways. These cells do not form an actual organ like the adrenal or thyroid glands. Instead, they are scattered throughout the body in organs like the lungs, stomach, and intestines.

Like most cells in your body, the lung neuroendocrine cells sometimes go through certain changes that cause them to grow too much and form tumors. These are known as neuroendocrine tumors or neuroendocrine cancers. There are 4 types of neuroendocrine lung tumors:

  • Typical carcinoid tumor
  • Small cell carcinoma
  • Large cell neuroendocrine carcinoma

Typical carcinoid tumors of the lungs are not linked to smoking. They tend to be slow growing, and only rarely spread outside the lungs.

Atypical carcinoid tumors grow a little faster and are somewhat more likely to spread to other organs. Seen under a microscope, they have more cells in the process of dividing and look more like a fast-growing tumor. They are much less common than typical carcinoids. Some of the features of an atypical carcinoid that may be mentioned in your report include: mitotic figures or mitoses and necrosis .

Some carcinoid tumors can release hormone-like substances into the bloodstream, which might cause symptoms. Lung carcinoids do this far less often than carcinoid tumors that start in the intestines.

Also Check: Melanoma Forearm

What Are Scc’s Caused By

Cumulative, long-term exposure to ultraviolet radiation from the sun over your lifetime causes most SCCs. Daily year-round sun exposure, intense exposure in the summer months or on sunny vacations and the UV produced by indoor tanning devices all add to the damage that can lead to SCC. Experts believe that indoor tanning is contributing to an increase in cases among young women, who tend to use tanning beds more than others do.

Treating Squamous Cell Carcinoma Of The Skin

Treatment options for squamous cell skin cancer depend on the risk of the cancer coming back, which is based on factors like the size and location of the tumor and how the cancer cells look under a microscope, as well as if a person has a weakened immune system.

Most squamous cell skin cancers are found and treated at an early stage, when they can be removed or destroyed with local treatment methods. Small squamous cell cancers can usually be cured with these treatments. Larger squamous cell cancers are harder to treat, and fast-growing cancers have a higher risk of coming back.

In rare cases, squamous cell cancers can spread to lymph nodes or distant parts of the body. If this happens, treatments such as radiation therapy, immunotherapy, and/or chemotherapy may be needed.

Don’t Miss: Ductal Breast Cancer Survival Rates

What Is Well Differentiated Squamous Cell Carcinoma

Ill start by breaking down the terminology. Carcinoma is acancer derived from epithelial cells, which are the lining cellsthat make up the skin, lining of the gastrointestinal tract, liningof the respiratory tract, etc. Squamous cell is a particular typeof epithelial cell that is flat there are only certain places inthe body that have this type of epithelial cell. Welldifferentiated means the cells, while cancerous, are still typicalin shape, size and intracellular characteristics for the type ofcell they developed from.

Putting everything back together, this is a cancer derived fromthe cells of either the skin or a body cavity lining that is stillfairly normal appearing. Interpreting this, I would guess thecancer is associated with the skin and that the cancer is notlikely to have metastasized yet.

Contact The Skin Cancer Expert

Overview of Cutaneous Squamous Cell Carcinoma

Dr. Daniel C. Allison is a renowned orthopedic oncologist who has extensive expertise in diagnosing and treating various cancers including squamous cell and melanoma. He understands the complexities of cancer and is the ideal physician for providing you with a personalized treatment plan. Contact us today for a personal consultation at 310.683.4586 and learn how we can help you.

You May Like: What Is The Survival Rate For Melanoma

Also Check: Last Stage Of Cancer Symptoms

Stage Iii Squamous Cell Carcinoma

The tumor cells may be of any size at the original site. A stage III SCC has begun to invade the nearby lymph nodes on the side of the body of the original cancerous growth. This new growth is still under 3 cm in size. It may also have grown into the facial bones like the bones surrounding the eye or your jaw bone.9 It has not affected any other organs.10

Diagnosing Squamous Cell Carcinoma

The main way to diagnose squamous cell carcinoma is with a biopsy. This involves having a small piece of tissue removed from the suspicious area and examined in a laboratory.

In the laboratory, a pathologist will examine the tissue under a microscope to determine if it is a skin cancer. He or she will also stage the cancer by the number of abnormal cells, their thickness, and the depth of penetration into the skin. The higher the stage of the tumor, the greater the chance it could spread to other parts of the body.

Squamous cell carcinoma on sun-exposed areas of skin usually does not spread. However, squamous cell carcinoma of the lip, vulva, and penis are more likely to spread. Contact your doctor about any sore in these areas that does not go away after several weeks.

You May Like: How To Get Skin Cancer

Recommended Reading: Well Differentiated Squamous Cell Carcinoma Prognosis

How Serious Is My Invasive Well

I have been diagnosed with invasive well-differentiated squamous cell carcinoma, involving biopsy border. How serious is this? It is located about one inch below ear and 1 inch diagonally below jawline. I also take an immunosuppressant for an unrelated condition, which I understand can make the cancer more serious. From what I have read, because of its location this is quite serious. Am I going to die?

You May Like: How To Know If You Have Melanoma Skin Cancer

Does This Mean That The Tumor Has Invaded Deeply And Is Associated With A Poor Prognosis

Squamous cell carcinoma poorly differentiated. HE staining ...

No, all it means is that it is a true cancer . On a biopsy, only a small sample of tissue is removed, and the pathologist usually cannot tell how deeply the tumor is invading into the wall of the esophagus.

Some early, small cancers can be treated with a special procedure called an endoscopic mucosal resection , which removes only part of the inner lining of the esophagus. In other situations, an esophagectomy is needed, and the depth of invasion is measured when the entire tumor is removed at surgery.

You May Like: Melanoma Bone Cancer Life Expectancy

What Does It Mean If My Carcinoma Is Called Small Cell Carcinoma

Small cell carcinoma is a special type of lung cancer that tends to grow and spread quickly. Since it has often spread outside the lung at the time it is diagnosed, it is rarely treated with surgery. It is most often treated with chemotherapy, which might be combined with radiation. The chemotherapy used is different from what is used for other types of lung cancers.

Treating Advanced Squamous Cell Cancers

Lymph node dissection:Removing regional lymph nodes might be recommended for some squamous cell cancers that are very large or have grown deeply into the skin, as well as if the lymph nodes feel enlarged and/or hard. The removed lymph nodes are looked at under a microscope to see if they contain cancer cells. Sometimes, radiation therapy might be recommended after surgery.

Immunotherapy: For advanced squamous cell cancers that cant be cured with surgery or radiation therapy, one option might be using an immunotherapy drug such as cemiplimab or pembrolizumab . However, these drugs havent been studied in people with weakened immune systems, such as people who take medicines for autoimmune diseases or who have had an organ transplant, so the balance between benefits and risks for these people isnt clear.

Systemic chemotherapy and/or targeted therapy:Chemotherapy and targeted therapy drugs might be other options for patients with squamous cell cancer that has spread to lymph nodes or distant organs. These types of treatment might be combined or used separately.

Read Also: Stage 4 Basal Cell Carcinoma Life Expectancy

What Is The Normal Structure Of The Lung

When you breathe in, air enters through your mouth or nose and goes into your lungs through the trachea . The trachea divides into 2 tubes called the bronchi , which divide into smaller branches called bronchioles. At the end of the bronchioles are tiny air sacs known as alveoli or acini.

Many tiny blood vessels run through the alveoli. They absorb oxygen from the inhaled air into your blood and pass carbon dioxide from the body into the alveoli. This is expelled from the body when you breathe out. Taking in oxygen and getting rid of carbon dioxide are your lungs main functions.

Dont Miss: How Often Does Basal Cell Carcinoma Spread

Well Differentiated Squamous Cell Carcinoma

Squamous cell carcinomas Dr Fiona Lehane

Hi a family member has just been diagnosed with this can someone tell me how serious this is? Caused by over exposure to sun lump on the scalp.

Welcome to Cancer Chat, Hawk.

Im sorry youve not received a reply from anyone here yet.

Ive had a little look on the forum and found a similar conversation between another member and one of our cancer nurses, Jean. It might be of some help and reassurance: Skin cancer. It explains a little bit about the difference between basal cell skin cancer , and squamous cell skin cancer, the type of skin cancer that your family member has.

You May Like: How Is Skin Cancer Detected And Diagnosed

Recommended Reading: Skin Cancer Pictures Mayo Clinic

Invasive Moderately Differentiated Squamous Cell Carcinomawhat Does This Mean Severe Squamous Dysphasia Meaning Also Please

Ask U.S. doctors your own question and get educational, text answers â it’s anonymous and free!

Ask U.S. doctors your own question and get educational, text answers â it’s anonymous and free!

HealthTap doctors are based in the U.S., board certified, and available by text or video.

What Is Invasive Squamous Cell Carcinoma

Invasive squamous cell carcinoma is a type of cancer that occurs in the flat cells that make up the outer layer of skin and the linings of some organs, known as squamous cells. In this case, the word invasive means that the cancerous tumor has penetrated deeply into the skin or organ, as opposed to remaining a surface lesion. For example, in cases of invasive squamous cell carcinoma of the skin, the tumor may have penetrated into the dermis through the epidermis. Depending on the location, size, and severity of the tumor, there are several different courses of treatment that may be pursued.

Squamous cell carcinoma is the second most common type of skin cancer after basal cell carcinoma. Most often it is caused by exposure to UV rays, either through natural sunlight or by indoor tanning. People with fair skin are particularly susceptible. It can also occur in organs as diverse as the prostate, bladder, and larynx, although these are nowhere near as common as squamous cell skin cancer. Exposure to radiation or chemical carcinogens, as well as some inflammatory or scarring disorders, can also increase the risk of squamous cell cancer.

You May Like: Melanoma On Face Prognosis

The Clinical Study Of The Poorly Differentiated Head And Neck Squamous Cell Carcinoma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Verified September 2016 by Zhigang Huang, Beijing Tongren Hospital. Recruitment status was: Not yet recruitingFirst Posted : September 27, 2016Last Update Posted : September 28, 2016
  • Study Details
Condition or disease
Carcinoma, Squamous Cell

Head and neck Squamous Cell Carcinoma is one of the most common head and neck malignant tumors. Investigators found that several patients with early TNM stage and poor differentiated HNSCC had poor prognosis, yet someone with advanced TNM stage and well differentiated HNSCC had good prognosis. Hence, Investigators suggested that prognosis factors and survival rates probably related to the differentiation of HNSCC, and prognosis factor of poorly differentiated HNSCC were rare discussed and controversy. Investigating the prognostic factors of poorly differentiated HNSCC is undoubtedly crucial.

About this study ,inclusion criteria were the following parts:

AND the exclusion criteria were:

Differentiation And Inflammation Classification In Patients With Pcr


The pCR rate for patients with poorly differentiated tumors was 43.1% , which was higher than the pCR rates among patients with well and moderately differentiated tumors . Interestingly, the rate of pCR declined with the grade of inflammation, except in 1 case with no inflammatory response. However, no significant correlation was noted between the inflammation classification and pCR rate .

Table 2

Read Also: Does Amelanotic Melanoma Blanch When Pressed

General Survival Of Well

Highly differentiated oral squamous cell carcinoma is also a very serious disease. As for the cancer patients, how long they can survive depends entirely on the severity of the patients condition and the sensitivity of the patients body to drugs , And a reasonable treatment plan, each patient is different, this is different from person to person, some patients can take Chinese medicine in time after surgery, consolidate the effect, the medicine can reach the lesion, promote blood circulation and remove blood stasis, clear heat and detoxify, The residual cancer cells that are invisible to the naked eye are completely removed, so that the patient”s symptoms and pain can be reduced and the patient”s quality of life can be improved.


well-differentiated oral squamous cell carcinoma, if the patient finds it earlier and behaves reasonably for treatment They are very sensitive, and the drugs used can show very good efficacy for these patients, so that these patients can get faster treatment and can extend their lifespan.

Highly differentiated oral squamous cell carcinoma, if the patient can maintain a good mentality, actively cooperate with the doctors treatment, do not have too much noise pressure, often feel comfortable, dont put his condition on the heart And, patients like this can prolong life.


What Are The Types Of Squamous Cell Carcinoma

Squamous cell carcinoma develops when the flat cells in the toplayer of skin grow and divide in an uncontrolled way.

You can get an SCC wherever there are squamous cells which is in manydifferent parts of the body. However, typically they appear on parts of theskin that have been exposed to a lot of ultraviolet radiation from the sunor from tanning beds.

An early form of skin cancer, called Bowen’s disease, which looks like a red, scaly patch, can also develop into an SCC if nottreated.

An SCC can be quite an aggressive cancer if left untreated. If you evernotice a sore, scab or scaly patch of skin that doesnt heal within 2 months,see a doctor.

Read Also: Stage 3 Melanoma Survival Rate


Popular Articles