How Dangerous Is Melanoma
Melanoma is usually curable when detected and treated early. Once melanoma has spread deeper into the skin or other parts of the body, it becomes more difficult to treat and can be deadly.
- The estimated five-year survival rate for U.S. patients whose melanoma is detected early is about 99 percent.
- An estimated 7,180 people will die of melanoma in the U.S. in 2021.
What Types Of Skin Cancers Are Deadly
Skin cancers are some of the most complex and serious conditions treated by dermatologists, and the U.S. Dermatology Partners team takes our role in preventing and treating all types of skin cancers very seriously. While some forms of skin cancer are not typically life-threatening, without proper treatment, there are serious health risks associated with all forms of skin cancer. According to Dr. Jessica Dorsey of U.S. Dermatology Partners in Cedar Park, Texas, Most skin cancers are slow-growing and unlikely to spread to other parts of the body, but without treatment, just about any form of skin cancer has the potential to be destructive or even fatal. Keep reading to learn more about the importance of regular screenings to catch skin cancer in the earliest stages and prevent the severe repercussions of untreated skin cancers.
What Does Mcc Look Like
MCC tumors often, but not always, appear on sun-exposed areas of the body. The tumors are not nearly as distinctive as other skin cancers and can appear as a pearly pimple-like lump, sometimes skin-colored, red, purple or bluish-red, though they are rarely tender to the touch. The rapid speed at which they grow is what often causes patients and doctors to take notice.
A recurrence of Merkel cell carcinoma on the forehead.
Merkel cell carcinoma on the lower leg.
Please note: Since not all Merkel cell carcinomas have the same appearance, these photos serve as a general reference for what MCC can look like. If you see something new, changing or unusual on your skin, schedule an appointment with your doctor. Photos courtesy of Paul Nghiem, MD, PhD
Also Check: What Is Stage 4 Melanoma Cancer
Visit Us Dermatology Partners
If youve been diagnosed with skin cancer or are concerned about a lesion that may be cancerous, contact U.S. Dermatology Partners to schedule an appointment right away. You can complete our online scheduling request any time, and one of our team members will be in touch to finalize your appointment details. We care deeply about you and the health of your skin!
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What Happens If Merkel Cell Carcinoma Is Left Untreated

Merkel cell carcinoma is a rare but aggressive and potentially fatal form of skin cancer. It typically affects people above the age of 50 and those who have weakened immune systems. In most cases, Merkel cell carcinoma begins as a skin-toned growth that may bleed easily. The bumps or nodules may also have blue, purple, or red coloring. Because the Merkle cells are near nerve endings, this form of cancer has numerous health risks, and if left untreated, Merkle cell cancer may spread to the brain, lungs, or bones, becoming fatal.
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What Are Basal And Squamous Cell Skin Cancers
Basal and squamous cell skin cancers are the most common types of skin cancer. They start in the top layer of skin , and are often related to sun exposure.
Cancer starts when cells in the body begin to grow out of control. Cells in nearly any part of the body can become cancer cells. To learn more about cancer and how it starts and spreads, see What Is Cancer?
Knowledge Is Your Best Defense
What Is Skin Cancer?
Skin cancer is the out-of-control growth of abnormal cells in the epidermis, the outermost skin layer, caused by unrepaired DNA damage that triggers mutations. These mutations lead the skin cells to multiply rapidly and form malignant tumors. The main types of skin cancer are basal cell carcinoma , squamous cell carcinoma , melanoma and Merkel cell carcinoma .
The two main causes of skin cancer are the suns harmful ultraviolet rays and the use of UV tanning beds. The good news is that if skin cancer is caught early, your dermatologist can treat it with little or no scarring and high odds of eliminating it entirely. Often, the doctor may even detect the growth at a precancerous stage, before it has become a full-blown skin cancer or penetrated below the surface of the skin.
Americans will develop skin cancer by age 70.
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The Bottom Line On Rare Skin Cancers
Sebaceous carcinoma, Merkel cell carcinoma, and dermatofibroma sarcoma protuberans are rare skin cancers. However, it is important to know about them because they may be mistaken for other more benign conditions. This could delay their diagnosis and impact the prognosis.
If you develop any suspicious lumps or bumps on your skin, including your eyelid, be sure to see a dermatologist for a definitive diagnosis.
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Is Skin Cancer Genetic
40-50% of Americans who live to the age of 65 will have skin cancer at least once. The most common types of skin cancer in the United States are basal cell carcinoma and squamous cell carcinomas. These are referred to as non-melanoma skin cancers and are generally the result of sun exposure. Learn more about the effects of UV exposure.
Approximately one in 60 people will develop invasive, cutaneous melanoma during their lifetime. Malignant melanoma is a cancer that begins in the melanocytes, the pigment-producing cells in the skin. In fair-complexioned individuals worldwide, the majority of melanoma cases are related to environmental factors such as excessive ultraviolet radiation . However, about 5-10% of melanoma cases are inherited in an autosomal dominant fashion. In other words, parents with a defined genetic mutation have a 50/50 chance to pass on the susceptibility to each of their children regardless of gender. Learn more about melanoma.
Learn more about genetic testing or make an appointment with our experts at the Skin Cancer Program.
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What Is The Treatment Of Dfsp
Because DFSP rarely spreads to other parts of the body, patients most often live for many years after treatment. All patients diagnosed with DFSP should have close lifelong follow-up with dermatologists and medical professionals.
Three Rare Skin Cancers You Should Know About
By Fayne Frey, MD | Published 4/12/2020 0
Unlike basal cell carcinoma, the three rare skin cancers highlighted here are quite uncommon. They are important to know about, however, because they may be mistaken for more benign conditions, such as a bug bite or an eyelid stye. This can lead to a delay in diagnosis that could impact the prognosis.
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What Is A Melanocyte
Melanocytes are skin cells found in the upper layer of skin. They produce a pigment known as melanin, which gives skin its color. There are two types of melanin: eumelanin and pheomelanin. When skin is exposed to ultraviolet radiation from the sun or tanning beds, it causes skin damage that triggers the melanocytes to produce more melanin, but only the eumelanin pigment attempts to protect the skin by causing the skin to darken or tan. Melanoma occurs when DNA damage from burning or tanning due to UV radiation triggers changes in the melanocytes, resulting in uncontrolled cellular growth.
About Melanin
Naturally darker-skinned people have more eumelanin and naturally fair-skinned people have more pheomelanin. While eumelanin has the ability to protect the skin from sun damage, pheomelanin does not. Thats why people with darker skin are at lower risk for developing melanoma than fair-skinned people who, due to lack of eumelanin, are more susceptible to sun damage, burning and skin cancer.
Our Approach To Basal Cell And Squamous Cell Carcinoma

UCSF provides superior, proven care to prevent, detect and manage basal cell and squamous cell carcinomas, and will tailor cutting-edge treatment plans to the individual patient. Our dermatologists, medical and surgical oncologists, radiation oncologists and dermatopathologists are known for providing the best treatment options and cure rates for skin cancer, while giving outstanding cosmetic results.
Some of our new diagnostic and treatment techniques include lymph node mapping to detect early occurrences of cancer, electron beam radiation and Mohs micrographic surgery, which removes the smallest amount of healthy tissue in order to minimize scarring and preserve skin function. We also offer our patients access to educational programs, resources for emotional support and opportunities to participate in experimental treatments.
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Skin Cancer Support Groups And Counseling
Living with skin cancer presents many new challenges for you and for your family and friends. You will probably have many worries about how the cancer will affect you and your ability to “live a normal life,” that is, to care for your family and home, to hold your job, and to continue the friendships and activities you enjoy.
Many people with a skin cancer diagnosis feel anxious and depressed. Some people feel angry and resentful others feel helpless and defeated. For most people with skin cancer, talking about their feelings and concerns helps. Your friends and family members can be very supportive. They may be hesitant to offer support until they see how you are coping. Don’t wait for them to bring it up. If you want to talk about your concerns, let them know.
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Some people don’t want to “burden” their loved ones, or prefer talking about their concerns with a more neutral professional. A social worker, counselor, or member of the clergy can be helpful. Your dermatologist or oncologist should be able to recommend someone.
Many people with cancer are profoundly helped by talking to other people who have cancer. Sharing your concerns with others who have been through the same thing can be remarkably reassuring. Support groups for people with cancer may be available through the medical center where you are receiving your treatment. The American Cancer Society also has information about support groups throughout the U.S.
What It Looks Like
Squamous cell cancer involves the runaway growth of keratinocytes, cells in the outermost layer of skin, which produce the protein keratin. Squamous means scaly in 60%80% of cases, the lesions emerge on or near scaly patches called actinic keratoses that develop from sun-damaged skin.
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- Explore options for better nutrition and exercise
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Get To Know Your Skin
Any changes to your skin, including new growths, sores that wont heal, or changes to existing moles or freckles, should be brought to the attention of a dermatologist.
Evaluating your skin through regular self-exams will give you a baseline for what your skin is supposed to look like. That way, when any changes occur, youll be able to spot them easily.
Diagnosis Of Skin Cancer
It is important to check your skin regularly and check with your doctor if you notice any changes.
In the majority of cases, your GP will examine you, paying attention to any spots that may look suspicious. Your GP may perform a biopsy . In some cases your GP may refer you to a specialist, such as a dermatologist, if necessary.
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What Is Nonmelanoma Skin Cancer
Skin cancer is a disease that begins in the cells of the skin. The area of skin with the cancer is often called a lesion. There are several types of skin cancer . Melanoma is the most serious. But there are others that are known as nonmelanoma skin cancer. These include:
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Basal cell carcinoma
Basal cell carcinoma and squamous cell carcinoma are by far the most common.
What Is The Treatment Of Merkel Cell Carcinoma
Once a Merkel cell carcinoma is diagnosed, and studies are performed to determine if the tumor has spread treatment options might include:
- Surgery is the most common treatment for Merkel Cell Carcinoma. The tumor is removed in addition to a margin of normal skin surrounding the tumor to assure the complete removal of the cancer. Often times, regional lymph nodes in the area of the tumor are removed at the same time to assess whether the tumor has spread. Spread to lymph nodes is found in approximately one-half of patients.
- Radiation Therapy. Following surgery, localized radiation therapy at the tumor site is commonly used to destroy the remaining cancer cells. Radiation therapy is also used in patients when surgery is not an option due to ill health, certain tumor locations or if the tumor has reoccurred after initial treatment.
- Chemotherapy. Following surgery, chemotherapy may be initiated especially when Merkel cell carcinoma has spread to lymph nodes, distant parts of the body, or has reoccurred after initial therapy.
When diagnosed and treated early, Merkel cell carcinoma can be controlled and even cured.
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Recurrent Basal Cell Carcinoma
Basal cell carcinomas are the most common type of skin cancer, according to the American Cancer Society. These cancers develop within the basal cell layer of the skin, in the lowest part of the epidermis.
Patients who have had basal cell carcinoma once have an increased risk of developing a recurrent basal cell cancer. Basal cell cancers may recur in the same location that the original cancer was found or elsewhere in the body. As many as 50 percent of cancer patients are estimated to experience basal cell carcinoma recurrence within five years of the first diagnosis.
Basal cell carcinomas typically grow slowly, and it is rare for them to metastasize or spread to nearby lymph nodes or other parts of the body. But early detection and treatment are important.
After completing treatment for basal cell carcinoma, it is important to perform regular self-examinations of the skin to look for new symptoms, such as unusual growths or changes in the size, shape or color of an existing spot. Skin cancers typically develop in areas of the body that are exposed to the sun, but they may also develop in areas with no sun exposure. Tell your oncologist or dermatologist about any new symptoms or suspicious changes you may have noticed.
- Have a history of eczema or dry skin
- Have been exposed to high doses of UV light
- Had original carcinomas several layers deep in the skin
- Had original carcinomas larger than 2 centimeters
What Is A Merkel Cell

Merkel cells are located deep in the top layer of skin. Merkel cells are connected to nerves, signaling touch sensation as touch receptors. MCC was named after Merkel cells due to the similar microscopic features however, recent research suggests that it is unlikely that MCC originates directly from normal Merkel cells.
Normal Merkel cells in the skin: In this illustration of a cross-section of the skin, normal Merkel cells are shown in red and connect to nerves shown in yellow. The structures drawn include the epidermis , dermis , and deeper adipose layer containing the fatty tissue. Arteries are depicted in red and veins are blue. Figure copyright by Paul Nghiem & Quade Medical Group.
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It Affects People Of All Races Genders And Ages Which Is Why It’s Absolutely Critical For Americans To Learn About
Here are the top 10 cancer hospitals in the usa. As the saying goes, eyes are the window to the soul, so it is important to keep them as sharp and clear as possible. Cancer is a common cause of death, but treatment has improved vastly over the past decade. Unfortunately, accidents, age or genes can lead to a loss of full or partial vision, leaving us with a foggy or blurred vie. Some hospitals are more renowned than others, of course. It can often cure early stage melanomas. Learn about melanoma surgery options here. Although it is the most commonly diagnosed cancer in american women, breast cancer can impact people of all genders. The strongest risk factor for developing skin cancer is ultraviolet ray exposure, typically from the sun. As with any ranking of cancer hospitals, this list provides a few prestigious names but doesn’t. There are a number of different treatments doctors recommend. Surgery is the main treatment for most melanomas. Some types of skin cancer are more dangerous than others, but if you have a spot.