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What Does Adapalene Do For The Skin

What Should I Avoid While Using Adapalene Topical

How I Cleared My Skin | My experience with Differin & Tretinoin

Avoid exposure to sunlight or tanning beds. Adapalene can make you sunburn more easily. Wear protective clothing and use sunscreen when you are outdoors.

Avoid using other skin medications that contain sulfur, resorcinol, or salicylic acid .

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.

What Is Differin Gel How Does It Compare To Differin Cream

Differin is produced in two formulations: a gel, and a cream. Differin gel is transparent and quite dense – when applied, it will be absorbed relatively quickly. Differin cream, though, is white and much oilier – it will take longer to be absorbed, but it also has moisturizing properties that will help if the affected area is uncomfortably dry.

In most cases, the gel formulation of Differin is easier to use because it applies clear and soaks into the skin rapidly, but it will depend on your particular case. If you’re not sure, you may want to try each form to see which you prefer.

What Is The Difference Between Aging Vs Photoaging

As we have discussed, aging is normal and a number of intrinsic factors contribute to the skins aging appearance. However, extrinsic or outside causes can also add to, or even accelerate the aging process. One prime culprit is the sun itself.

is aging that is induced by UV light exposure. UV light penetrates through the skin and disrupts DNA at the cellular level, prematurely aging the skin. Furthermore, this DNA damage increases the risk of developing skin cancer.

All unprotected skin is susceptible to photoaging, but not everyone will be affected equally. Skin tone and geographic location affect ones risk. In general, people with lighter skin and those living closer to the equator are more prone to photoaging.

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Collagen Elastin & Glycosaminoglycan: Why Does Skin Age

As people grow older, their skin naturally loses its youthful look over time due to a combination of decreases in collagen, elastin, and glycosaminoglycans as well as changes in exfoliation.

Skin Aging Due to Collagen

Collagen is a protein responsible for the firmness and structure of the skin. Though collagen is commonly associated with the skin, it is also found in the bones as well. Your body naturally makes collagen from amino acids but it can also be ingested in the form of powder supplements. Decreases in collagen production with age lead to thinner, less firm skin in comparison to ones younger years. In fact, it has been estimated that once you hit your 20s, you lose about 1% of collagen each year. That is an approximate 10% loss by the time someone is age 30!

Skin Aging Due to Elastin

Elastin is another type of protein found in the body. As its name eludes, it brings elasticity and stretchiness to the skin. Its purpose is to give the skin its ability to retain its shape after being stretched. Decreased elastin means that the skin does not bounce back as easily as it did before. For example, if you were to pinch the skin and then release it on the average 80-year-old skin versus 20-year-old skin, the former would take longer to return to the baseline state because of different elastin levels.

Skin Aging Due to Glycosaminoglycan

How To Cope With The Differin Purge

8 month update using 0.3% adapalene (+ 2.5% BP) :) : tretinoin

This purging phase is threatening because it can lead acne sufferers to think that the Differin isn’t actually going to work, causing them to stop applying it and seek alternative treatment. While Differin isn’t right for everyone, you should have your symptoms inspected before you even think about discontinuing treatment.

In most cases, all that must be done to escape the purge is to endure it for a week or so. Once all the blockages lurking beneath the surface have been cleared, the skin can begin to truly get better, and Differin shines in this regard – users often continue to see improvement for many months after beginning treatment.

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Posted In Acne Skin Care

By Allison Dinh, The University of Texas at Austin College of Pharmacy

Curist delivers FDA-approved allergy medicines to your door at half the price of traditional brands. We hope everyone stays safe and healthy during this time.

Adapalene is known to be used for treating acne, but did you know that it also has anti-aging benefits? Continue to read below about this holy grail ingredient touted by dermatologists and skincare experts!

How Long Does Differin Take To Work

Differin takes time to work. Some people will notice an improvement within two to three weeks. Acne may temporarily worsen before getting better. You can expect benefits in eight to 12 weeks with continued use.

If you dont see an improvement in your skin condition after 12 weeks of constant use, follow up with your healthcare provider to see if you should stop this medication.

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Healthy Alternatives To Differin

In order to avoid the worrying side effects of Differin, there are fortunately many alternatives that can clear your acne with much safer ingredients.

Vitamin A

Differin is a retinoid, meaning it is derived from Vitamin A. But through supplements or through a healthy diet, you can include Vitamin A as an ingredient in your skincare treatment without having to worry about photosensitivity or potentially worsening your acne.

Vitamin A supplements can be a healthier and more natural way to contribute to your skin health without needing to use Differin gel.

Azelaic Acid

Differin works by increasing cell turnover which exfoliates your skin and thus may clear out excess dead skin cells and bacteria trapped inside your pores.

Azelaic Acid does the same thing, but it doesn’t lead to photosensitivity.

That’s why we chose to bypass Differin as an ingredient when making our Clearing Tonic, instead opting for Azelaic Acid as one of the active ingredients.

A Skin Care Routine

Typically, one single ingredient won’t get rid of your acne, simply because acne is caused by a variety of factors. While one ingredient, like Azelaic Acid, can clear out clogged pores, you would still need other ingredients to treat the other causes of acne such as inflammation and excess of P. acnes bacteria.

Retinoids like Differin dry out your skin and can lead to inflammation. A holistic skincare routine with calming ingredients like passionflower can be a better alternative.

Does Differin Gel Really Work

My Favourite Acne Treatments – Adapalene | Dr Sam Bunting

The short answer is yes. Most dermatologists love and recommend Differin Gel, and the slew of positive reviews probably speak for themselves. Additionally, as an older 2006 study pointed out, Differin Gel is a good option for people who have had acne and are looking for a product that will help prevent future acne.

While this study examined a stronger suspension of adapalene, the results showed reduced scarring in patients who used this treatment over a 4-month period.

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How Should I Use This Medication

This medicine is for external use only, do not take by mouth. Follow the directions on the prescription label. Make sure the skin is clean and dry. Apply just enough to cover the affected area. Rub in gently. Do not get in the eyes, inside the nose, on wounds, or any other sensitive areas of skin.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What Side Effects Are Possible With This Medication

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who uses this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people using this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • burning or stinging
  • skin irritation

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • excessively dry, red, swollen, or blistered skin

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

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How Do I Take Adapalene For Anti

Adapalene is applied once a day topically to the skin on the face. This application can be anytime during the day, either in the morning or at night. Before applying adapalene, you first need to cleanse your face and allow it to dry. Then, you will take a pea-sized amount of adapalene from the tube. Spread it in a thin layer on your entire face, taking care to avoid the eyes and lips. That may seem like too small of an amount, but that is all that you will need! Any more than that would be too irritating to the skin. When it comes to skincare, less is more.

Differin Gel Vs Tretinoin Cream

Differin Adapalene Gel 0.1% Acne Treatment 15g 30 Day Supply 0.5 Ounce ...

A common alternative to Differins adapalene is tretinoin, a medication used to treat acne and sun damage. Like adapalene, tretinoin has also been found to improve the appearance of wrinkles, fine lines, and dark spots.

Tretinoin is a form of retinoic acid and is also known as Retin-A. The prescription-strength topical cream works by irritating the skin and speeding up the life cycle of skin cells. It makes the cells divide and die faster, promoting the production of newer and healthier cells.

Tretinoin is a synthetic version of vitamin A. This means that its stronger, and youll have to obtain a prescription for the product. Its also stronger than retinol and isnt tolerated as well by sensitive skin.

You should steer clear of tretinoin if youre:

  • frequently exposed to the sun

If youre on any other medications, you should tell your doctor to make sure it wont interact with tretinoin.

Tretinoin is also used topically. You should wash your face and wait 20 to 30 minutes before applying the medication to the specific areas that you need it.

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What Are Warnings And Precautions For Adapalene


This medication contains adapalene. Do not take Differin if you are allergic to adapalene or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


  • Hypersensitivity to adapalene or any of its components

Effects of Drug Abuse

  • Minimize UV light exposure use sunscreen and protective clothing
  • Extreme weather may cause skin irritation
  • Adverse reaction risk higher during first month of treatment generally subsides with use
  • Do not apply product to abrasions or cuts or to eczematous or sunburned skin
  • Skin irritation: Apply moisturizer, reduce application frequency, or discontinue
  • Do not wax treated area or apply topical products that may further irritate skin
  • Discontinue immediately and consult physician if any anaphylactoid/anaphylactic reactions occur

Pregnancy and Lactation

  • Use adapalene with caution during pregnacy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • Adapalene excretion in breast milk is unknown use with caution if breastfeeding.

Are There Any Other Precautions Or Warnings For This Medication

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Area of use: Adapalene is for external use only. Do not apply to areas near the eyes, lips, angles of the nose, mucous membranes, and open wounds.

Cosmetics: Avoid the use of certain cosmetics that might make your skin worse. Ask a cosmetician for non-comedogenic cosmetics or use water-based makeup. Remove any makeup before applying adapalene.

Sunlight: Avoid exposure to excessive sunlight . If sun exposure cannot be avoided, use a sunscreen . Waxing as a hair removal method should be avoided.

Pregnancy: Women who are pregnant or considering pregnancy should not use adapalene. Women who use adapalene should ensure that they are using adequate birth control while they are using this medication.

Breast-feeding: It is not known if adapalene passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children under the age of 12.

Seniors: The safety and effectiveness of using this medication have not been established for people over the age of 65.

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Some Side Effects Can Be Serious If You Experience Any Of These Symptoms Call Your Doctor Immediately Or Get Emergency Medical Treatment:

  • hives, itching, shortness of breath or difficulty breathing
  • swelling of the eyes, face, lips, tongue, or throat

Adapalene may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s MedWatch Adverse Event Reporting program online or by phone .

More Information About Glycerin

Retinoids That Don’t Burn: All About Adapalene Gel

Though Graf says its best used as a moisturizer, it is safe and beneficial to use it as a serum as well. When considering how to add glycerin to your skin care routine, it is best to think about what you want to achieve with this ingredient, says Engelman. If the goal is to support and maintain hydration throughout the day, a serum is a great choice as it will be absorbed and can sustain layering other skin care ingredients on top. If the goal is to heal or prevent moisture loss, a thicker, more occlusive cream may be well-suited.

Because of its minimal side effects, she adds that glycerin is safe to use every day. Just be aware of your individual skin type and concerns, she says. Make sure to use glycerin in a way that best supports your skins health.


Dr. Dendy Engelman, M.D., FACMS, FAAD, board-certified cosmetic dermatologist and Mohs surgeon at the Shafer Clinic.

Dr. Jeannette Graf, M.D., board-certified dermatologist and assistant clinical professor of dermatology at the Mount Sinai School of Medicine.

Studies referenced:

Widyarman, A., Drestia, A., Bachtiar, E., Bachtiar, B. . The Anti-inflammatory Effects of Glycerol-supplemented Probiotic Lactobacillus reuteri on Infected Epithelial cells In vitro. Contemp Clin Dent. 2018 Apr-Jun 9:298-303.

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Dosage: How Much Differin Should I Use

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form :
  • Adults and teenagersApply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well.
  • ChildrenUse and dose must be determined by your doctor.

Adapalene Use During Pregnancy

Most experts recommend stopping the use of retinoid treatments during pregnancy,¹² and adapalene is no exception.¹³ Studies on animals did not show an increased risk of birth defects with adapalene. But any risk to pregnant women is unknown. In other words, we cant confirm its safe for pregnant humans yet.

Women who are pregnant, planning to become pregnant, or breast-feeding should consult with a doctor before using acne treatments.

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Differin Purge: How Long Does It Last And How To Cope With It

Differin is one of the most effective and widely-used acne treatments on the market, but it can require an eight week purge period’ and cause other side effects.

You need to consider a lot before purchasing, so it’s a good idea to do your research before spending your money.

Below we discuss the Differin purge, how to cope with it and the difference between Differin purge and suffering from a reaction.

What Are The Side Effects Of Adapalene

Differin Adaplene Gel 45g

Adapalene is less irritating compared to other topical retinoids. The adverse effects of adapalene are usually relatively mild. They include skin irritation, redness, dry skin, itching, burning sensation, and photosensitivity . Although theyre rare, allergic reactions are possible with adapalene, with symptoms that can include itching and swelling of the face, lips, and skin around the eyes.

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