How Is Skin Cancer Formed

Squamous Cell Carcinoma In Situ

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DermNet NZ

Squamous cell carcinoma in situ, also known as Bowens disease, is a precancerous condition that appears as a red or brownish patch or plaque on the skin that grows slowly over time. The patches are often found on the legs and lower parts of the body, as well as the head and neck. In rare cases, it has been found on the hands and feet, in the genital area, and in the area around the anus.

Bowens disease is uncommon: only 15 out of every 100,000 people will develop this condition every year. The condition typically affects the Caucasian population, but women are more likely to develop Bowens disease than men. The majority of cases are in adults over 60. As with other skin cancers, Bowens disease can develop after long-term exposure to the sun. It can also develop following radiotherapy treatment. Other causes include immune suppression, skin injury, inflammatory skin conditions, and a human papillomavirus infection.

Bowens disease is generally treatable and doesnt develop into squamous cell carcinoma. Up to 16% of cases develop into cancer.

How Common Is It

Nearly 152,000 cases of non melanoma skin cancer are diagnosed in the UK each year. The number could be higher as we know that they are under reported. This makes it the most common type of cancer by far. Because non melanoma skin cancers are easy to treat and cure, they’re often left out of national cancer statistics.

Different Types Of Cancer Start In The Skin

Skin cancer may form in basal cells or squamous cells. Basal cell carcinoma and squamous cell carcinoma are the most common types of skin cancer. They are also called nonmelanoma skin cancer. Actinic keratosis is a skin condition that sometimes becomes squamous cell carcinoma.

Melanoma is less common than basal cell carcinoma or squamous cell carcinoma. It is more likely to invade nearby tissues and spread to other parts of the body.

This summary is about basal cell carcinoma, squamous cell carcinoma of the skin, and actinic keratosis. See the following PDQ summaries for information on melanoma and other kinds of cancer that affect the skin:

• Genetics of Skin Cancer

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How Dangerous Is Melanoma

Melanoma is usually curable when detected and treated early. Once melanoma has spread deeper into the skin or other parts of the body, it becomes more difficult to treat and can be deadly.

• The estimated five-year survival rate for U.S. patients whose melanoma is detected early is about 99 percent.
• An estimated 7,180 people will die of melanoma in the U.S. in 2021.

How Is Skin Cancer Diagnosed

First, your dermatologist may ask you if you have noticed any changes in any existing moles, freckles or other skin spots or if youve noticed any new skin growths. Next, your dermatologist will examine all of your skin, including your scalp, ears, palms of your hands, soles of your feet, between your toes, around your genitals and between your buttocks.

If a skin lesion is suspicious, a biopsy may be performed. In a biopsy, a sample of tissue is removed and sent to a laboratory to be examined under a microscope by a pathologist. Your dermatologist will tell you if your skin lesion is skin cancer, what type you have and discuss treatment options.

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Can You Have Melanoma For 3 Years And Not Know

How long can you have melanoma and not know it? It depends on the type of melanoma. For example, nodular melanoma grows rapidly over a matter of weeks, while a radial melanoma can slowly spread over the span of a decade. Like a cavity, a melanoma may grow for years before producing any significant symptoms.

Exposure To Sun Over Time

Because we are living longer, we are exposed to more sun during our lifetime. This means skin cancer is more common than it used to be. Skin cancer is more common in people over the age of 40 and becomes more common with age. But the number of younger people developing skin cancer is also rising.

People who work outdoors for example, farm workers, builders and gardeners have a greater risk. This is because they are exposed to the sun for long periods of time.

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Faq: How Is Skin Cancer Formed

Skin cancer develops when one of the three types of cells that make up your skin reproduce abnormally. As they grow and divide without stopping, they can metastasize. This means they spread to other places in your body through your lymphatic system. Most skin cancers are caused by exposure to ultraviolet light.

What Are The Symptoms Of Skin Cancer

Skin cancers first appear as a spot, lump or scaly area on the skin, or a mole that changes colour, size or shape over several weeks or months. These changes can appear anywhere on the body, particularly areas frequently exposed to the sun. Skin cancers may bleed and become inflamed, and can be tender to the touch.

There are certain characteristics to look for in spots and moles. Remember the ‘ABCDE’ of skin cancer when checking your skin:

• Asymmetry does each side of the spot or mole look different to the other?
• Border is it irregular, jagged or spreading?
• Colours are there several, or is the colour uneven or blotchy?
• Diameter look for spots that are getting bigger
• Evolution is the spot or mole changing or growing over time?

Changes may include an area that is scaly, shiny, pale or bright pink in colour, or a spot or lump that grows quickly and is thick, red, scaly or crusted.

See your doctor if you notice any new spots or an existing spot that changes size, shape or colour over several weeks or months. Your doctor can help you distinguish between a harmless spot such as a mole, and a sunspot or irregular mole that could develop later into skin cancer.

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Basal Cell Carcinoma: The Most Common Skin Cancer

Basal cell carcinoma, which is also called basal cell skin cancer, is the most common form of skin cancer, accounting for about 80 percent of all cases.

Rates of basal cell carcinoma have been increasing. Experts believe this is due to more sun exposure, longer lives, and better skin cancer detection methods.

This type of cancer begins in the skins basal cells, which are found in the outermost layer, the epidermis. They usually develop on areas that are exposed to the sun, like the face, head, and neck.

Basal cell carcinomas may look like:

• A flesh-colored, round growth
• A pinkish patch of skin
• A bleeding or scabbing sore that heals and then comes back

They typically grow slowly and dont spread to other areas of the body. But, if these cancers arent treated, they can expand deeper and penetrate into nerves and bones.

Though its rare, basal cell carcinoma can be life-threatening. Experts believe that about 2,000 people in the United States die each year from basal cell carcinoma or squamous cell carcinoma.

Some risk factors that increase your chances of having a basal cell carcinoma include:

• Being exposed to the sun or indoor tanning
• Having a history of skin cancer
• Being over age 50
• Having chronic infections, skin inflammation, or a weakened immune system
• Being exposed to industrial compounds, radiation, coal tar, or arsenic
• Having an inherited disorder, such as nevoid basal cell carcinoma syndrome or xeroderma pigmentosum

Can You Use Wart Remover On Skin Cancer

A common form of skin cancer has been treated successfully with a cream used to battle warts. Basal-cell carcinoma is traditionally cured by surgery, freezing or laser treatment, all of which can leave scars. But the wart cream imiquimod, marketed as Aldara, may bring a pain-free way of dealing with the ailment.

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Prognosis For Skin Cancer

It is not possible for a doctor to predict the exact course of a disease. However, your doctor may give you the likely outcome of the disease. If detected early, most skin cancers are successfully treated.

Most non-melanoma skin cancers do not pose a serious risk to your health but a cancer diagnosis can be a shock. If you want to talk to someone see your doctor. You can also call Cancer Council 13 11 20.

What Does Stage 1 Melanoma Look Like

Stage 1: The cancer is up to 2 millimeters thick. It has not yet spread to lymph nodes or other sites, and it may or may not be ulcerated. Stage 2: The cancer is at least 1 mm thick but may be thicker than 4 mm. It may or may not be ulcerated, and it has not yet spread to lymph nodes or other sites.

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What Happens If Basal Cell Carcinoma Is Left Untreated

Basal cell carcinoma is the most common type of skin cancer, and it is considered very low risk for metastasizing and spreading to other parts of the body. It is typically very slow-progressing and is usually diagnosed and treated in very early stages. If left untreated, basal cell carcinomas can be locally destructive to the tissues where it grows, and it can invade deeper structures such as nerves, cartilage, and even bone. In most cases, basal cell carcinoma develops on the face, ears, neck, head, shoulders, hands, and other areas that receive frequent sun exposure. The tumors may look like raised bumps on the skin that are usually smooth and pearly/shiny in appearance. Blood vessels can sometimes be seen within the lesions, and in some cases, a wound may form and bleed easily.

What Happens If Precancers Go Untreated

As the name suggests, precancers are damaged skin cells that arent considered cancerous, but if they are left untreated, these lesions are at high risk to become skin cancer. There are two main types of precancerous skin conditions: actinic keratosis and dysplastic nevi. Actinic keratosis looks like a rough, scaly patch of the skin that is usually red or brown. This condition may develop into squamous cell carcinoma if left untreated.

Nevi are moles, and dysplastic nevi is a term that means a mole is abnormal. Dysplastic nevi may develop into melanoma without proper treatment. While precancerous skin cancers are not malignant on their own, the potential to develop into life-threatening forms of this condition means they need to be evaluated regularly.

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Types Of Genes That Cause Cancer

The genetic changes that contribute to cancer tend to affect three main types of genesproto-oncogenes, tumor suppressor genes, and DNA repair genes. These changes are sometimes called drivers of cancer.

Proto-oncogenes are involved in normal cell growth and division. However, when these genes are altered in certain ways or are more active than normal, they may become cancer-causing genes , allowing cells to grow and survive when they should not.

Tumor suppressor genes are also involved in controlling cell growth and division. Cells with certain alterations in tumor suppressor genes may divide in an uncontrolled manner.

DNA repair genes are involved in fixing damaged DNA. Cells with mutations in these genes tend to develop additional mutations in other genes and changes in their chromosomes, such as duplications and deletions of chromosome parts. Together, these mutations may cause the cells to become cancerous.

As scientists have learned more about the molecular changes that lead to cancer, they have found that certain mutations commonly occur in many types of cancer. Now there are many cancer treatments available that target gene mutations found in cancer. A few of these treatments can be used by anyone with a cancer that has the targeted mutation, no matter where the cancer started growing.

Skin Cancer Symptoms And Signs

Basal Cell Carcinoma

BCC is the most common type of skin cancer and has a predilection for sun-exposed skin. Tumors may appear as a pearly or waxy bumps usually with visible blood vessels , or as a flat scaly reddish patch with a brown border, or as a hard or scar-like lesion . Frequently BCCs can be itchy, often bleed, or in more advanced cases, ulcerate.

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Staging For Basal Cell Carcinoma And Squamous Cell Carcinoma Of The Skin Depends On Where The Cancer Formed

Staging for basal cell carcinoma and squamous cell carcinoma of the eyelid is different from staging for basal cell carcinoma and squamous cell carcinoma found on other areas of the head or neck. There is no staging system for basal cell carcinoma or squamous cell carcinoma that is not found on the head or neck.

Surgery to remove the primary tumor and abnormal lymph nodes is done so that tissue samples can be studied under a microscope. This is called pathologic staging and the findings are used for staging as described below. If staging is done before surgery to remove the tumor, it is called clinical staging. The clinical stage may be different from the pathologic stage.

Infiltrative Basal Cell Carcinoma

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DermNet NZ

Infiltrative basal cell carcinoma occurs when a tumor makes its way into the dermis via thin strands between collagen fibers. This aggressive type of skin cancer is harder to diagnose and treat because of its location. Typically, infiltrative basal cell carcinoma appears as scar tissue or thickening of the skin and requires a biopsy to properly diagnose.

To remove this type of basal cell carcinoma, a specific form of surgery, called Mohs, is used. During a Mohs surgery, also called Mohs micrographic surgery, thin layers of skin are removed until there is no cancer tissue left.

This photo contains content that some people may find graphic or disturbing.

DermNet NZ

Superficial basal cell carcinoma, also known as in situ basal-cell carcinoma, tends to occur on the shoulders or the upper part of the torso, but it can also be found on the legs and arms. This type of cancer isnt generally invasive because it has a slow rate of growth and is fairly easy to spot and diagnose. It appears reddish or pinkish in color and may crust over or ooze. Superficial basal cell carcinoma accounts for roughly 15%-26% of all basal cell carcinoma cases.

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Skin Cancer Is A Disease In Which Malignant Cells Form In The Tissues Of The Skin

The skin is the bodys largest organ. It protects against heat, sunlight, injury, and infection. Skin also helps control body temperature and stores water, fat, and vitamin D. The skin has several layers, but the two main layers are the epidermis and the dermis . Skin cancer begins in the epidermis, which is made up of three kinds of cells:

• Squamous cells: Thin, flat cells that form the top layer of the epidermis.
• Basal cells: Round cells under the squamous cells.
• Melanocytes: Cells that make melanin and are found in the lower part of the epidermis. Melanin is the pigment that gives skin its natural color. When skin is exposed to the sun, melanocytes make more pigment and cause the skin to darken.

Skin cancer can occur anywhere on the body, but it is most common in skin that is often exposed to sunlight, such as the face, neck, and hands.

Preparing For Your Appointment

If you have any concerns about the health of your skin, it is important to share them with your doctor. After making an appointment, there are steps you can take to prepare yourself and make the most of your time with your doctor.

Here are some things to consider and be prepared to discuss before visiting the clinic or hospital:

• What symptoms are you experiencing ?

• When did you first notice your symptoms?

• Have there been any major changes or stressors in your life recently?

• What medications and/or vitamins are you taking?

• What questions do you have for your doctor?

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How The Government Of Canada Protects You

The Public Health Agency of Canada monitors cancer in Canada. PHAC identifies trends and risk factors for cancer, develops programs to reduce cancer risks, and researches to evaluate risks from the environment and human behaviours. Health Canada also promotes public awareness about sun safety and the harmful effects of UV rays.

A Dangerous Skin Cancer

Melanoma is a serious form of skin cancer that begins in cells known as melanocytes. While it is less common than basal cell carcinoma and squamous cell carcinoma , melanoma is more dangerous because of its ability to spread to other organs more rapidly if it is not treated at an early stage.

Learn more about melanoma types, risk factors, causes, warning signs and treatment.

Melanoma Fact

Only 20-30% of melanomas are found in existing moles.

While 70-80% arise on normal-looking skin.

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Are There Complications Of Skin Cancer Treatment

Most skin cancer treatments involve some localised damage to surrounding healthy skin such as swelling, reddening or blistering of the skin where the cancer is removed. Your doctor will explain any specific risks, which may include:

• pain or itching where the skin has been treated, or if lymph nodes have been removed
• scarring or changes to skin colour, after a skin cancer has been removed
• bleeding during or after surgery for more complicated skin cancers
• reactions sometimes your body may react to medicines used in treatment or surgery
• lymphoedema if your lymph nodes have been removed your neck, arm or leg may swell with fluid.

Its best to manage complications as early as possible, so ask your doctor for advice.